High frequency of new recombinant forms in HIV-1 transmission networks demonstrated by full genome sequencing.

HIV-1 epidemic in Belgium mainly driven by the MSM. In these patients subtype B predominates but the presence of an increase in population of non-B subtypes have been reported. We aimed to determine the extent to which the increase in the heterogeneity of subtypes in high risk populations induces the formation and deployment of a new recombinant form. This study focused on the transmission network which reflects the local transmission to the important ones.

One hundred and five HIV-1 transmission clusters were identified after 2849 phylogenetic analysis of HIV-1 pol sequences generated for the purpose of drug resistance test basis between 2013 and 2017. Of this group 105, 62 extended in size over the last two years and therefore considered as representing continuous transmission. These 62 clusters including 774 patients in total. From each cluster between 1 and 3 patient representatives have been selected to close the full-length viral genome sequencing. In total, 101 patients full genome sequence generated. Indications for the presence of recombinant forms newfound to 10 clusters.

DiscoveryProbe? DNA Damage/DNA Repair Library

L1033-.25 250 uL/well(10 mM solution)
EUR 8286

DiscoveryProbe? DNA Damage/DNA Repair Library

L1033-5 5 mg/well
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DNA-Fect

DF37100-1 1 ml
EUR 418.8

DNA-Fect293

DF37293-1 1 ml
EUR 349.2

DNA-fectamine

DNAF001 1ml
EUR 334.57

T7 DNA

310-005 200µg
EUR 98.4

T7 DNA

310-025 5x200 µg
EUR 270

DNA antibody

10C-CR6034M1 100 ug
EUR 289.2
Description: Mouse monoclonal DNA antibody

DNA antibody

10R-D114b 100 ug
EUR 672
Description: Mouse monoclonal DNA antibody

DNA antibody

10-D20A 500 ug
EUR 591.6
Description: Mouse monoclonal DNA antibody

DNA Antibody

abx023805-02mg 0.2 mg
EUR 777.6

DNA Polymerase

ABD3082 100 ug
EUR 525.6

DNA pol

ABF9055 100 ug
EUR 525.6

DNA Polymerase

ABF5235 100 ug
EUR 525.6

pBR322 DNA

MSD14 50ug
EUR 183.19

pUC18 DNA

G40-300 50µg
EUR 67.2

pUC18 DNA

G40-305 5x50µg
EUR 176.4

Activated DNA

80605 500 µL
EUR 125
Description: Activated DNA for PARP assay, for use with BPS's assay kits for PARPs 1, 2, 3, and 6. PARP1 Chemiluminescent Assay Kit, #80551 ; PARP2 Chemiluminescent Assay Kit, #80552; PARP3 Chemiluminescent Assay Kit, #80553; PARP6 Chemiluminescent Assay Kit, #80556; PARP2 Homogeneous Assay Kit, #80702

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AD-146-B Custom Ask for price

Taq DNA polymerase (TQ21) , DNA Aptamer, unlabeled

AD-146-U Custom Ask for price

DNA Ligase I (DNA Ligase I) Antibody

abx232431-100ug 100 ug
EUR 577.2

Mouse Anti-DNA Antibody (DNA) ELISA Kit

abx257816-96tests 96 tests
EUR 895.2

DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)

N150 500 units
EUR 122.4

DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)

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DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)

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Human DNA-directed DNA/RNA polymerase mu (POLM)

1-CSB-EP889065HU
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  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
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  • 200ug
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Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in E.coli

Human DNA-directed DNA/RNA polymerase mu (POLM)

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  • EUR 1080.00
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Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in Yeast

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Human DNA-directed DNA/RNA polymerase mu (POLM)

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Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in Baculovirus

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Description: Recombinant protein for human DNA-directed DNA/RNA polymerase mu

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Maximo DFS-Plus Taq DNA Polymerase DNA-free

N140 500 units
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Description: Mouse monoclonal DNA PKcs antibody

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ClearSight DNA Stain

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BIOTAQ DNA Polymerase

BIO-21040 500 Units Ask for price

IMMOLASE DNA Polymerase

BIO-21046 250 Units Ask for price

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Human Genomic DNA

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AceTaq DNA Polymerase

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Taq DNA Polymerase

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DL5000 DNA Marker

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DL5000 DNA Marker

MD102-02 500 μl
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DL15000 DNA Marker

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DL15000 DNA Marker

MD103-02 500 μl
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pUC 18 DNA

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DNA Pure Kit

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DNA Pure Kit

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DNA Loading Dye

G030 6X; 3 x 1.0 ml
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Kodaq DNA Polymerase

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These 10 clusters represented 105 patients or 13.6% of the patients covered by the study. The findings clearly show that the new recombinant strains that contribute to local transmission, even in epidemic largely driven MSM and subtype B. It is an evolution that needs to be monitored as a genomic fragment reshuffled through recombination can affect the transmissibility of viruses and pathology of infection. In addition, important changes in the virus genome sequence can be challenging performance tests used for diagnosis, patient monitoring and analysis of drug resistance.

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